Telomerase Research Paper

Telomerase Research Paper-45
We cross-sectionally tested telomere length in different tissues of two long-lived (naked mole-rat and Spalax) and two short-lived (rat and mice) species to tease out this enigma.

We cross-sectionally tested telomere length in different tissues of two long-lived (naked mole-rat and Spalax) and two short-lived (rat and mice) species to tease out this enigma.

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It is thus of high clinical relevance, and is often measured in easily-accessible blood monocytes.

In contrast, telomerase activity is highly up-regulated and associated with tumorigenesis by maintaining telomeres and, thereby, constituting an important pre-requisite for the ongoing proliferation of cancer cells.

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Telomere dynamics have been found to be better predictors of survival and mortality than chronological age.Please visit the Instructions for Authors page before submitting a manuscript.There is an Article Processing Charge (APC) for publication in this open access journal. Submitted papers should be well formatted and use good English.It also extends the function of telomerase in its non-canonical role to cell types such as neurons, and organs such as brain.The aim of this Special Issue is to demonstrate and share new results and the growing knowledge about the roles of telomeres and telomerase during processes such as aging and cancer development. Gabriele Saretzki Manuscript Submission Information Manuscripts should be submitted online at com by registering and logging in to this website. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website.Both r LTL (0.79 ± 0.14) and DNAm age (69.67 ± 7.27 years) were available for 773 subjects (31.6% female; mean chronological age= 69.68 ± 11.01 years; mean DNAm age acceleration = −0.01 ± 7.83 years).While we detected a significant correlation between chronological age and DNAm age (n = 779, R = 0.69), we found neither evidence of an association between r LTL and the DNAm age (β = 3.00, p = 0.18) nor r LTL and the DNAm age acceleration (β = 2.76, p = 0.22) in the studied cohort, suggesting that DNAm age and r LTL measure different aspects of biological age.Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers).All manuscripts are thoroughly refereed through a single-blind peer-review process.Telomeres, the caps that protect the end of linear chromosomes, are known to shorten with age, inducing cell senescence and aging.Furthermore, differences in age-related telomere attrition [...] Read more.

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