Phd Thesis Nanoparticles

Phd Thesis Nanoparticles-49
The results demonstrate that size and surface charge of Au NP interact in an interrelated fashion to modulate nanoparticle internalization by cells, providing an engineering strategy for designing nanomaterials for drug delivery applications.Later, I engineered an environmentally responsive nanoparticle-protein interface for real time hydrogen peroxide (H) sensing and monitoring of cellular oxidative stress.

The results demonstrate that size and surface charge of Au NP interact in an interrelated fashion to modulate nanoparticle internalization by cells, providing an engineering strategy for designing nanomaterials for drug delivery applications.Later, I engineered an environmentally responsive nanoparticle-protein interface for real time hydrogen peroxide (H) sensing and monitoring of cellular oxidative stress.

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Several functionalities are typically added onto nanocarriers but the most crucial feature of those carriers intended to be administered intravenously is that they should possess a long residence time in blood circulation.

The present review focusses on the mesoporous nanoparticles due to their great promise in nanomedicine and concentrates on their coatings because it is the outmost layer which dictates their first interactions with the surroundings and often determines their biofate.

In the first investigation, a MFand the CPP penetratin were found to increase m NP delivery to cells grown in3D.

In the second investigation, Au NPs were assessed in a range of different celltypes (grown in 2D) for their performance in 4 main areas; cellular toxicity,cellular uptake, c-myc knockdown and effect on the cell cycle.

This feat can be aided by the attachment of additional functionalmolecules such as cell penetrating peptides (CPPs), targeting peptides,additional drug types and molecules for imaging during treatment.

Manydifferent NP design strategies are currently under development.TY - THEST1 - Removal of engineered nanoparticles in drinking water treatment processes AU - Floris, Roberto PY - 2017/3/3Y1 - 2017/3/3N2 - Nanotechnology has brought a large number of engineered nanomaterials and nanoparticles to applications in multiple daily products and in almost every sector of society.AB - Nanotechnology has brought a large number of engineered nanomaterials and nanoparticles to applications in multiple daily products and in almost every sector of society.Nanotechnology has brought a large number of engineered nanomaterials and nanoparticles to applications in multiple daily products and in almost every sector of society.The many advantages that this relatively new science has brought to our daily life are evident, but still little is known on the potential environmental and human risk posed by nanotechnology applications.The main problem facing the development of these novel therapies isthe specific delivery of nucleic acids into diseased cells within the body.It ishoped that nanoparticles (NPs) can be used to overcome this problem, by actingas vehicles to transport nucleic acids through the body for specific delivery intodiseased cells.This thesis investigates the removal and removal mechanisms of engineered nanomaterials and nanoparticles in simulated drinking water treatment plants.It focuses on how engineered nanomaterials and nanoparticles affect process performances and which treatments are best to follow for their removal.In summary, the findings in this thesis highlight that systematically tuning the physicochemical properties of nanoparticles provides a powerful means to control interactions with biological systems, enabling new biological and therapeutic applications.The exploitation of various inorganic nanoparticles as drug carriers and therapeutics is becoming increasingly common.

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