Bone Density And Antiepileptic Drugs A Case-Controlled Study

Bone Density And Antiepileptic Drugs A Case-Controlled Study-27
Deficiency of Vitamin D is commonly described as a cause for the bone loss in epileptic patients while others being decreased absorption of calcium, increased PTH levels, and inhibition of calcitonin secretion, etc.

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Many biochemical abnormalities have been shown be associated with the use of AEDs such as hypocalcemia, hypophosphatemia, reduced serum levels of Vitamin D (biologically active metabolites), and increase in parathormone (PTH) levels.

Alkaline phosphatase, osteocalcin, and C-terminal extension peptide of Type I procollagen which are the markers of bone turnover and cross-linked carboxyterminal telopeptide of human Type I collagen and hydroxyproline which are the markers of bone resorption are found to be elevated.

Over the past decade, there has been a proliferation of new AEDs which have been approved, promising a better quality of life with lesser adverse effects for many with epilepsy.

However, the question now arises whether the newer AEDs, such as lamotrigine, gabapentin, vigabatrin, levetiracetam, and topiramate cause little or no adverse bone changes.

It is very important to have knowledge and understanding of the possible metabolic derangements associated with AED use as most of the bone effects remain subclinical for a long time and may take years to manifest clinically.

The incidence of seizures and epilepsy is high in childhood and in the elderly, especially after the age of 60 years.

Impact of antiepileptic drugs on bone health: Need for monitoring, treatment, and prevention strategies.

J Family Med Prim Care [serial online] 2016 [cited 2019 Sep 6];8-53. 2016/5/2/248/192338 Medical treatment with antiepileptic drugs (AEDs) is the main-stay of treatment.

The AEDs are increasingly being used for nonseizure indications such as neurological disorders such as neuropathic pain, essential tremor, prophylaxis of migraine and psychiatric disorders including anxiety, bipolar disorder, schizophrenia, and behavioral disturbance in dementia.

One of the major concerns with the use of AEDs is the occurrence of significant metabolic effects on the bone as AED treatment is given for years or lifelong.


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